Emodin에 의한 Myeloid Cell Leukemia-1 단백질 억제를 통한 점액표피양암종세포주에서의 apoptosis 유도 기전
Apoptotic Effect of Emodin through Down-Regulation of Myeloid Cell Leukemia-1 in Mucoepidermoid Carcinoma Cells
최경희, 조남표, 조성대,
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최경희 ( Choi Kyeong-Hee ) - 전북대학교 치의학전문대학원 구강병리학교실
조남표 ( Cho Nam-Pyo ) - 전북대학교 치의학전문대학원 구강병리학교실
조성대 ( Cho Sung-Dae ) - 전북대학교 치의학전문대학원 구강병리학교실
KMID : 0829220110350010001
Abstract
Emodin is a bioactive compound isolated from the root and rhizomes of Rheum plamatum L. (polygenaceae), which is known as a traditional Chinese and Japanese medicine. In the present study, the effect of emodin on YD-15 mucoepidermoid carcinoma cells and its molecular mechanism were investigated. This study shows that emodin significantly inhibits the growth of YD-15 cells. Activation of caspase-3 and PARP is triggered by emodin and it increases sub-G1 population and the number of YD-15 cells with nuclear condensation and fragmentation. In addition, we found that emodin significantly decreases myeloid cell leukemia 1(MCL-1). These results suggest that MCl-1 is an important molecule for emodin-induced apoptosis. Taken together, emodin inhibits cell viability and induces apoptosis via down-regulation of MCL-1 and it can be a new potent anticancer drug candidate for the treatment of mucoepidermoid carcinoma.
키워드
Mucoepidermoid carcinoma cells; Emodin; Apoptosis; Myeloid cell leukemia 1
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